arm64
Apple Silicon
M-series Macs
macOS 14 Sonoma or newer
Download for Apple SiliconVerify download (SHA-256)
88d6b71e6e6d7c9664f2537b9c5437777e20f501227cfa870d1c38dea51cd865SIMLAB DESKTOP
Your molecular workspace.
On your computer.
Visualize structures, dock molecules and prepare simulations in one desktop app. Your local scientific tools are bundled and ready to use.
GET THE APP
Choose your operating system
Separate builds for the right architecture.
macOS
Choose the chip inside your Mac.
x64
Intel
Intel-powered Macs
macOS 14 Sonoma or newer
Download for IntelVerify download (SHA-256)
c1e21f79e255d07c57d22918b462ab5b140faec7cd24b217c96c17f167da62d9Windows
For 64-bit Intel and AMD computers.
x64
Windows 64-bit
Intel or AMD PCs running 64-bit Windows
Windows 10 (1809+) or Windows 11
Download for Windows 64-bitVerify download (SHA-256)
672baedf00e83e17d917b1840f0d66557e5b30efb22418e81dddd4aa99d0f9acLinux
For 64-bit Intel and AMD computers.
x64
Linux AppImage
Portable application for compatible Linux distributions
x86_64 · glibc 2.36 or newer
Download AppImageVerify download (SHA-256)
ee097960c2612f70a151f5f3e8b3deba4a5f8d6be1c822235b68e76a28e52c96x64
Debian / Ubuntu
Package for Debian 12 or Ubuntu 24.04 and newer
amd64 · 64-bit Intel or AMD
Download Debian packageVerify download (SHA-256)
c8f37f698d55bc51e27bb12286bceb9a29dcbe1b774f1a50ce86a08073b04cffInstallers include the scientific engines. Allow additional space for installation, projects and simulation results. Keep your existing projects backed up when updating.
Not sure which download to choose?
On a Mac
Open Apple menu → About This Mac. If it lists a Chip such as Apple M1 or M4, choose Apple Silicon. If it lists an Intel processor, choose Intel.
Both editions require macOS 14 or newer.
On Windows
Open Settings → System → About → System type. Choose this installer for a 64-bit operating system, x64-based processor.
A 32-bit Windows edition and a native Windows ARM edition are not currently available.
ACTIVATE YOUR WORKSPACE
Your desktop license, right here.
Copy the shared license below and paste it into SimLab Desktop when it first opens. No separate license account is needed.
Connect to the internet for activation.
Desktop activation is separate from GPU Compute. Compute requires your own SimLab account, access and credits.
FROM DOWNLOAD TO FIRST PROJECT
Installation, step by step
Install on macOS
Both Mac editions are signed and notarized. Choose the edition matching your Mac’s chip.
- Download the matching Mac edition.Check your chip and macOS version using About This Mac.
- Open the .dmg file.Drag SimLab Desktop into your Applications folder. If updating, quit the running app first.
- Open SimLab Desktop.Launch it from Applications, then paste the shared license while online.
- Start exploring.Open the Viewer directly, or create a project and import your structures.
If macOS reports a problem
Stop installation and download a fresh copy from this page. Check the SHA-256 checksum above and contact support with the exact message if the problem continues. Keep macOS security protections enabled.
About opening downloaded apps on a Mac ↗Install on Windows
- Download the 64-bit installer.Save the .exe file to your computer and wait for the download to finish.
- Run the installer.Choose your installation location and follow the setup steps.
- Launch SimLab Desktop.Open it from the Start menu or desktop shortcut, then paste the shared license while online.
- Open a structure or project.The scientific tools are included; no separate GROMACS or Python installation is needed.
If Windows shows a protection prompt
Check that the file came from simlabscience.com and compare its SHA-256 checksum above. If you trust the file and Windows offers the option, select More info → Run anyway. If your organization blocks installation, contact its IT team.
Install on Linux
- Choose one package.Use the DEB package on Debian 12 / Ubuntu 24.04 or newer, or AppImage on a compatible x86_64 distribution.
- Install or allow the app to run.For DEB, open your terminal in Downloads and run
sudo apt install ./SimLab-Desktop-0.1.14-LocalLab-Linux-amd64.deb. For AppImage, enable “Allow executing file as program” in its properties, then open it. - Activate and open Local Lab.Paste the shared license while online. Choose a course folder to run GROMACS commands locally.
If AppImage does not open
Your distribution may need FUSE support. On supported Debian or Ubuntu systems, use the DEB package instead. Keep the application sandbox enabled and contact support if startup is blocked.
WHAT’S NEW
A smoother SimLab experience
Version 0.1.14 · Early access
- Local Lab. Improved Mac startup and clearer terminal controls.
- Docking your way. Choose pocket-guided or whole-protein blind docking.
- Clearer pocket previews. Improved structure loading and error recovery.
- Update controls. Check for new versions from the app.
Early access: native Windows and Linux installation checks remain pending. Intel Mac checks used Rosetta.
A few useful answers
Where are the terminal tools’ licenses and source files?
Do I need to install GROMACS, Python or RDKit?
No. The desktop installers include the tools needed by the supported local workflows.
Can I work offline?
Activate while connected to the internet, then use the local tools offline. Online services—including GPU Compute, remote DFT and fetching structures or compounds—need an internet connection. License validation may also require reconnecting.
How will app updates work?
Install this version once if you are upgrading from 0.1.13 or earlier. The app checks for newer releases while online. Choose Update now to download, then Restart and update after finishing your local work. You can also use the downloads above.
Why is the download large?
The installer includes scientific engines, a Python environment and ADMET model files so local work does not depend on installing those tools separately.